Cupertino, California is located in Santa Clara County. Below is a market update video for Santa Clara County. For detailed market report of your neighborhood, please contact us. Cupertino, California, is on the western edge of Silicon Valley against the foothills of the Santa Cruz Mountains. With a population of 64,000 people within 13 square miles, Cupertino is 42 miles south of San Francisco and is home to high-tech companies, most notably Apple Inc.